RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming
RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming
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Author / Creator
Yin, Huilong , Zhang, Xiang , Yang, Pengyuan , Zhang, Xiaofang , Peng, Yingran , Li, Da , Yu, Yanping , Wu, Ye , Wang, Yidi , Zhang, Jinbao , Ding, Xiaochen , Wang, Xiangpeng , Yang, Angang and Zhang, Rui
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
N6-methyladenosine (m6A) is a reversible mRNA modification that has been shown to play important roles in various biological processes. However, the roles of m6A modification in macrophages are still unknown. Here, we discover that ablation of Mettl3 in myeloid cells promotes tumour growth and metastasis in vivo. In contrast to wild-type mice, Mett...
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Full title
RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_013f4347490a418eb0ba0440e7fbe53f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_013f4347490a418eb0ba0440e7fbe53f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-21514-8
