Characterization of a re-engineered, mesothelin-targeted Pseudomonas exotoxin fusion protein for lun...
Characterization of a re-engineered, mesothelin-targeted Pseudomonas exotoxin fusion protein for lung cancer therapy
About this item
Full title
Author / Creator
Bauss, Frieder , Lechmann, Martin , Krippendorff, Ben-Fillippo , Staack, Roland , Herting, Frank , Festag, Matthias , Imhof-Jung, Sabine , Hesse, Friederike , Pompiati, Marc , Kollmorgen, Gwendlyn , da Silva Mateus Seidl, Rita , Bossenmaier, Birgit , Lau, Wilma , Schantz, Christian , Stracke, Jan O. , Brinkmann, Ulrich , Onda, Masanori , Pastan, Ira , Bosslet, Klaus and Niederfellner, Gerhard
Publisher
United States: Elsevier B.V
Journal title
Language
English
Formats
Publication information
Publisher
United States: Elsevier B.V
Subjects
More information
Scope and Contents
Contents
Mesothelin overexpression in lung adenocarcinomas correlates with the presence of activating KRAS mutations and poor prognosis. Hence SS1P, a mesothelin-targeted immunotoxin, could offer valuable treatment options for these patients, but its use in solid tumor therapy is hampered by high immunogenicity and non-specific toxicity. To overcome both ob...
Alternative Titles
Full title
Characterization of a re-engineered, mesothelin-targeted Pseudomonas exotoxin fusion protein for lung cancer therapy
Authors, Artists and Contributors
Author / Creator
Lechmann, Martin
Krippendorff, Ben-Fillippo
Staack, Roland
Herting, Frank
Festag, Matthias
Imhof-Jung, Sabine
Hesse, Friederike
Pompiati, Marc
Kollmorgen, Gwendlyn
da Silva Mateus Seidl, Rita
Bossenmaier, Birgit
Lau, Wilma
Schantz, Christian
Stracke, Jan O.
Brinkmann, Ulrich
Onda, Masanori
Pastan, Ira
Bosslet, Klaus
Niederfellner, Gerhard
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_016854fb9481433287e7d8721af2694e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_016854fb9481433287e7d8721af2694e
Other Identifiers
ISSN
1574-7891
E-ISSN
1878-0261
DOI
10.1016/j.molonc.2016.07.003
