Loss of CLN3 in microglia leads to impaired lipid metabolism and myelin turnover
Loss of CLN3 in microglia leads to impaired lipid metabolism and myelin turnover
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Loss-of-function mutations in
CLN3
cause juvenile Batten disease, featuring neurodegeneration and early-stage neuroinflammation. How loss of CLN3 function leads to early neuroinflammation is not yet understood. Here, we have comprehensively studied microglia from
Cln3
∆ex7/8
mice, a genetically accurate disease model. Loss of CLN3 fu...
Alternative Titles
Full title
Loss of CLN3 in microglia leads to impaired lipid metabolism and myelin turnover
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TN_cdi_doaj_primary_oai_doaj_org_article_0249f9c9d7da49e085adce9537d2335d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0249f9c9d7da49e085adce9537d2335d
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ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-024-07057-w
