A proline switch explains kinetic heterogeneity in a coupled folding and binding reaction
A proline switch explains kinetic heterogeneity in a coupled folding and binding reaction
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The interactions of intrinsically disordered proteins (IDPs) with their molecular targets are essential for the regulation of many cellular processes. IDPs can perform their functions while disordered, and they may fold to structured conformations on binding. Here we show that the
cis
/
trans
isomerization of peptidyl−prolyl bonds can h...
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Full title
A proline switch explains kinetic heterogeneity in a coupled folding and binding reaction
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TN_cdi_doaj_primary_oai_doaj_org_article_0300d09d545747a38524b19feaddaff8
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0300d09d545747a38524b19feaddaff8
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05725-0
