Tau local structure shields an amyloid-forming motif and controls aggregation propensity
Tau local structure shields an amyloid-forming motif and controls aggregation propensity
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Tauopathies are neurodegenerative diseases characterized by intracellular amyloid deposits of tau protein. Missense mutations in the tau gene (
MAPT
) correlate with aggregation propensity and cause dominantly inherited tauopathies, but their biophysical mechanism driving amyloid formation is poorly understood. Many disease-associated mutatio...
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Full title
Tau local structure shields an amyloid-forming motif and controls aggregation propensity
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TN_cdi_doaj_primary_oai_doaj_org_article_03b30e34ee8f4915b39c71a3c1b8c803
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_03b30e34ee8f4915b39c71a3c1b8c803
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-10355-1
