Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-deriv...
Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors
About this item
Full title
Author / Creator
Grohmann, Christoph , Walker, Francesca , Devlin, Mark , Luo, Meng-Xiao , Chüeh, Anderly C. , Doherty, Judy , Vaillant, François , Ho, Gwo-Yaw , Wakefield, Matthew J. , Weeden, Clare E. , Kamili, Alvin , Murray, Jayne , Po’uha, Sela T. , Weinstock, Janet , Kane, Serena R. , Faux, Maree C. , Broekhuizen, Esmee , Zheng, Ye , Shield-Artin, Kristy , Kershaw, Nadia J. , Tan, Chin Wee , Witchard, Helen M. , Ebert, Gregor , Charman, Susan A. , Street, Ian , Kavallaris, Maria , Haber, Michelle , Fletcher, Jamie I. , Asselin-Labat, Marie-Liesse , Scott, Clare L. , Visvader, Jane E. , Lindeman, Geoffrey J. , Watson, Keith G. , Burgess, Antony W. and Lessene, Guillaume
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Targeting cell division by chemotherapy is a highly effective strategy to treat a wide range of cancers. However, there are limitations of many standard-of-care chemotherapies: undesirable drug toxicity, side-effects, resistance and high cost. New small molecules which kill a wide range of cancer subtypes, with good therapeutic window in vivo, have...
Alternative Titles
Full title
Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors
Authors, Artists and Contributors
Author / Creator
Walker, Francesca
Devlin, Mark
Luo, Meng-Xiao
Chüeh, Anderly C.
Doherty, Judy
Vaillant, François
Ho, Gwo-Yaw
Wakefield, Matthew J.
Weeden, Clare E.
Kamili, Alvin
Murray, Jayne
Po’uha, Sela T.
Weinstock, Janet
Kane, Serena R.
Faux, Maree C.
Broekhuizen, Esmee
Zheng, Ye
Shield-Artin, Kristy
Kershaw, Nadia J.
Tan, Chin Wee
Witchard, Helen M.
Ebert, Gregor
Charman, Susan A.
Street, Ian
Kavallaris, Maria
Haber, Michelle
Fletcher, Jamie I.
Asselin-Labat, Marie-Liesse
Scott, Clare L.
Visvader, Jane E.
Lindeman, Geoffrey J.
Watson, Keith G.
Burgess, Antony W.
Lessene, Guillaume
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_041aa5232fd84ed8be1a33555359e8d7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_041aa5232fd84ed8be1a33555359e8d7
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-020-03269-0
