PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell developmen...
PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development
About this item
Full title
Author / Creator
Lau, Hwee Hui , Krentz, Nicole A. J. , Abaitua, Fernando , Perez-Alcantara, Marta , Chan, Jun-Wei , Ajeian, Jila , Ghosh, Soumita , Lee, Yunkyeong , Yang, Jing , Thaman, Swaraj , Champon, Benoite , Sun, Han , Jha, Alokkumar , Hoon, Shawn , Tan, Nguan Soon , Gardner, Daphne Su-Lyn , Kao, Shih Ling , Tai, E. Shyong , Gloyn, Anna L. and Teo, Adrian Kee Keong
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The coding variant (p.Arg192His) in the transcription factor
PAX4
is associated with an altered risk for type 2 diabetes (T2D) in East Asian populations. In mice,
Pax4
is essential for beta cell formation but its role on human beta cell development and/or function is unknown. Participants carrying the PAX4 p.His192 allele exhibited decr...
Alternative Titles
Full title
PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development
Authors, Artists and Contributors
Author / Creator
Krentz, Nicole A. J.
Abaitua, Fernando
Perez-Alcantara, Marta
Chan, Jun-Wei
Ajeian, Jila
Ghosh, Soumita
Lee, Yunkyeong
Yang, Jing
Thaman, Swaraj
Champon, Benoite
Sun, Han
Jha, Alokkumar
Hoon, Shawn
Tan, Nguan Soon
Gardner, Daphne Su-Lyn
Kao, Shih Ling
Tai, E. Shyong
Gloyn, Anna L.
Teo, Adrian Kee Keong
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_04c9903c45a041a292092f38195e3bde
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_04c9903c45a041a292092f38195e3bde
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-41860-z
