Metabolic Reprogramming via ACOD1 depletion enhances function of human induced pluripotent stem cell...
Metabolic Reprogramming via ACOD1 depletion enhances function of human induced pluripotent stem cell-derived CAR-macrophages in solid tumors
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Author / Creator
Wang, Xudong , Su, Siyu , Zhu, Yuqing , Cheng, Xiaolong , Cheng, Chen , Chen, Leilei , Lei, Anhua , Zhang, Li , Xu, Yuyan , Ye, Dan , Zhang, Yi , Li, Wei and Zhang, Jin
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The pro-inflammatory state of macrophages, underpinned by their metabolic condition, is essentially affecting their capacity of combating tumor cells. Here we find, via a pooled metabolic gene knockout CRISPR screen that KEAP1 and ACOD1 are strong regulators of the pro-inflammatory state in macrophages. We show that ACOD1 knockout macrophages, gene...
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Full title
Metabolic Reprogramming via ACOD1 depletion enhances function of human induced pluripotent stem cell-derived CAR-macrophages in solid tumors
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TN_cdi_doaj_primary_oai_doaj_org_article_0524e3bf5a574204933b90616f87c76a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0524e3bf5a574204933b90616f87c76a
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-41470-9
