PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in gl...
PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Angiogenesis is a hallmark of cancer. However, most malignant solid tumors exhibit robust resistance to current anti-angiogenic therapies that primarily target VEGF pathways. Here we report that endothelial-mesenchymal transformation induces glioblastoma (GBM) resistance to anti-angiogenic therapy by downregulating VEGFR-2 expression in tumor-assoc...
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Full title
PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma
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TN_cdi_doaj_primary_oai_doaj_org_article_055f0727bcaa4b70a85ef5c46234440d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_055f0727bcaa4b70a85ef5c46234440d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05982-z
