Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir
Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir
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Publisher
Washington: American Chemical Society
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Language
English
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Publisher
Washington: American Chemical Society
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Contents
The SARS-CoV-2 main protease (Mpro) is the drug target of Pfizer’s oral drug nirmatrelvir. The emergence of SARS-CoV-2 variants with mutations in Mpro raised the alarm of potential drug resistance. To identify potential clinically relevant drug-resistant mutants, we systematically characterized 102 naturally occurring Mpro mutants located at 12 res...
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Full title
Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir
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TN_cdi_doaj_primary_oai_doaj_org_article_05a36a36b769471388ffab230a57b808
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_05a36a36b769471388ffab230a57b808
Other Identifiers
ISSN
2374-7943
E-ISSN
2374-7951
DOI
10.1021/acscentsci.3c00538
