Synthesis and Biological Evaluation of Novel Biased Mu-Opioid Receptor Agonists
Synthesis and Biological Evaluation of Novel Biased Mu-Opioid Receptor Agonists
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Author / Creator
Guo, Yanhao , Yu, Ruimin , Zhang, Tao , Ren, Fengxia , Yu, Zixing , Cheng, Jingchao , Jia, Hongxin , Shi, Weiguo and Zhang, Yatong
Publisher
Switzerland: MDPI AG
Journal title
Language
English
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Publication information
Publisher
Switzerland: MDPI AG
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Contents
This study explored the potential of a series of PZM21 analogues for pain treatment. Specifically, the hydroxyphenyl ring of PZM21 was replaced with a naphthyl ring, the thienyl ring was substituted with either a phenyl ring or furan rings, and the essential dimethylamine and urea groups were retained. These compounds aimed to enhance safety and mi...
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Full title
Synthesis and Biological Evaluation of Novel Biased Mu-Opioid Receptor Agonists
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TN_cdi_doaj_primary_oai_doaj_org_article_0626dfa7d7794f97bdf996ed2d0f30cd
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0626dfa7d7794f97bdf996ed2d0f30cd
Other Identifiers
ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules29132961
