CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular ac...
CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Target engagement is a critical factor for therapeutic efficacy. Assessment of compound binding to native target proteins in live cells is therefore highly desirable in all stages of drug discovery. We report here the first compound library screen based on biophysical measurements of intracellular target binding, exemplified by human thymidylate sy...
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CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
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TN_cdi_doaj_primary_oai_doaj_org_article_07cf88c839fd460490c598e8b7898ec9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_07cf88c839fd460490c598e8b7898ec9
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2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms11040
