Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell a...
Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia
About this item
Full title
Author / Creator
Van Thillo, Quentin , De Bie, Jolien , Seneviratne, Janith A. , Demeyer, Sofie , Omari, Sofia , Balachandran, Anushree , Zhai, Vicki , Tam, Wai L. , Sweron, Bram , Geerdens, Ellen , Gielen, Olga , Provost, Sarah , Segers, Heidi , Boeckx, Nancy , Marshall, Glenn M. , Cheung, Belamy B. , Isobe, Kiyotaka , Kato, Itaru , Takita, Junko , Amos, Timothy G. , Deveson, Ira W. , McCalmont, Hannah , Lock, Richard B. , Oxley, Ethan P. , Garwood, Maximilian M. , Dickins, Ross A. , Uyttebroeck, Anne , Carter, Daniel R. , Cools, Jan and de Bock, Charles E.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Spi-1 Proto-Oncogene (SPI1)
fusion genes are recurrently found in T-cell acute lymphoblastic leukemia (T-ALL) cases but are insufficient to drive leukemogenesis. Here we show that
SPI1
fusions in combination with activating
NRAS
mutations drive an immature T-ALL in vivo using a conditional bone marrow transplant mouse model. Addition...
Alternative Titles
Full title
Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia
Authors, Artists and Contributors
Author / Creator
De Bie, Jolien
Seneviratne, Janith A.
Demeyer, Sofie
Omari, Sofia
Balachandran, Anushree
Zhai, Vicki
Tam, Wai L.
Sweron, Bram
Geerdens, Ellen
Gielen, Olga
Provost, Sarah
Segers, Heidi
Boeckx, Nancy
Marshall, Glenn M.
Cheung, Belamy B.
Isobe, Kiyotaka
Kato, Itaru
Takita, Junko
Amos, Timothy G.
Deveson, Ira W.
McCalmont, Hannah
Lock, Richard B.
Oxley, Ethan P.
Garwood, Maximilian M.
Dickins, Ross A.
Uyttebroeck, Anne
Carter, Daniel R.
Cools, Jan
de Bock, Charles E.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_097bfb27edca4477bb37a09172ff1f71
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_097bfb27edca4477bb37a09172ff1f71
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-24442-9
