Lymphatic-derived oxysterols promote anti-tumor immunity and response to immunotherapy in melanoma
Lymphatic-derived oxysterols promote anti-tumor immunity and response to immunotherapy in melanoma
About this item
Full title
Author / Creator
Sun, Mengzhu , Garnier, Laure , Chevalier, Romane , Roumain, Martin , Wang, Chen , Angelillo, Julien , Montorfani, Julien , Pick, Robert , Brighouse, Dale , Fournier, Nadine , Tarussio, David , Tissot, Stéphanie , Lobaccaro, Jean-Marc , Petrova, Tatiana V. , Jandus, Camilla , Speiser, Daniel E. , Kopf, Manfred , Pot, Caroline , Scheiermann, Christoph , Homicsko, Krisztian , Muccioli, Giulio G. , Garg, Abhishek D. and Hugues, Stéphanie
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
In melanoma, lymphangiogenesis correlates with metastasis and poor prognosis and promotes immunosuppression. However, it also potentiates immunotherapy by supporting immune cell trafficking. We show in a lymphangiogenic murine melanoma that lymphatic endothelial cells (LECs) upregulate the enzyme Ch25h, which catalyzes the formation of 25-hydroxych...
Alternative Titles
Full title
Lymphatic-derived oxysterols promote anti-tumor immunity and response to immunotherapy in melanoma
Authors, Artists and Contributors
Author / Creator
Garnier, Laure
Chevalier, Romane
Roumain, Martin
Wang, Chen
Angelillo, Julien
Montorfani, Julien
Pick, Robert
Brighouse, Dale
Fournier, Nadine
Tarussio, David
Tissot, Stéphanie
Lobaccaro, Jean-Marc
Petrova, Tatiana V.
Jandus, Camilla
Speiser, Daniel E.
Kopf, Manfred
Pot, Caroline
Scheiermann, Christoph
Homicsko, Krisztian
Muccioli, Giulio G.
Garg, Abhishek D.
Hugues, Stéphanie
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_0af122abda854646bb7ed8b7aa8c081f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0af122abda854646bb7ed8b7aa8c081f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-55969-w
