Sortilin restricts secretion of apolipoprotein B-100 by hepatocytes under stressed but not basal con...
Sortilin restricts secretion of apolipoprotein B-100 by hepatocytes under stressed but not basal conditions
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United States: American Society for Clinical Investigation
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Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Genetic variants at the SORT1 locus in humans, which cause increased SORT1 expression in the liver, are significantly associated with reduced plasma levels of LDL cholesterol and apolipoprotein B (apoB). However, the role of hepatic sortilin remains controversial, as genetic deletion of sortilin in mice has resulted in variable and conflicting effe...
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Full title
Sortilin restricts secretion of apolipoprotein B-100 by hepatocytes under stressed but not basal conditions
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TN_cdi_doaj_primary_oai_doaj_org_article_0af7b8d00cb24cf5aeabcd9ab4fe24f7
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0af7b8d00cb24cf5aeabcd9ab4fe24f7
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ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI144334
