Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dysl...
Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dyslipidemia, subclinical atherosclerosis, and diabetes cardiovascular complications among East Asians
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Author / Creator
Tam, Claudia H. T. , Lim, Cadmon K. P. , Luk, Andrea O. Y. , Ng, Alex C. W. , Lee, Heung-man , Jiang, Guozhi , Lau, Eric S. H. , Fan, Baoqi , Wan, Raymond , Kong, Alice P. S. , Tam, Wing-hung , Ozaki, Risa , Chow, Elaine Y. K. , Lee, Ka-fai , Siu, Shing-chung , Hui, Grace , Tsang, Chiu-chi , Lau, Kam-piu , Leung, Jenny Y. Y. , Tsang, Man-wo , Kam, Grace , Lau, Ip-tim , Li, June K. Y. , Yeung, Vincent T. F. , Lau, Emmy , Lo, Stanley , Fung, Samuel , Cheng, Yuk-lun , Chow, Chun-chung , Hu, Miao , Yu, Weichuan , Tsui, Stephen K. W. , Huang, Yu , Lan, Huiyao , Szeto, Cheuk-chun , Tang, Nelson L. S. , Ng, Maggie C. Y. , So, Wing-yee , Tomlinson, Brian , Chan, Juliana C. N. , Ma, Ronald C. W. , The Hong Kong Diabetes Biobank Study Group , The Hong Kong Diabetes Register TRS Study Group , Hong Kong Diabetes Biobank Study Group and Hong Kong Diabetes Register TRS Study Group
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central Ltd
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More information
Scope and Contents
Contents
The clinical utility of personal genomic information in identifying individuals at increased risks for dyslipidemia and cardiovascular diseases remains unclear.
We used data from Biobank Japan (n = 70,657-128,305) and developed novel East Asian-specific genome-wide polygenic risk scores (PRSs) for four lipid traits. We validated (n = 4271) and s...
Alternative Titles
Full title
Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dyslipidemia, subclinical atherosclerosis, and diabetes cardiovascular complications among East Asians
Authors, Artists and Contributors
Author / Creator
Lim, Cadmon K. P.
Luk, Andrea O. Y.
Ng, Alex C. W.
Lee, Heung-man
Jiang, Guozhi
Lau, Eric S. H.
Fan, Baoqi
Wan, Raymond
Kong, Alice P. S.
Tam, Wing-hung
Ozaki, Risa
Chow, Elaine Y. K.
Lee, Ka-fai
Siu, Shing-chung
Hui, Grace
Tsang, Chiu-chi
Lau, Kam-piu
Leung, Jenny Y. Y.
Tsang, Man-wo
Kam, Grace
Lau, Ip-tim
Li, June K. Y.
Yeung, Vincent T. F.
Lau, Emmy
Lo, Stanley
Fung, Samuel
Cheng, Yuk-lun
Chow, Chun-chung
Hu, Miao
Yu, Weichuan
Tsui, Stephen K. W.
Huang, Yu
Lan, Huiyao
Szeto, Cheuk-chun
Tang, Nelson L. S.
Ng, Maggie C. Y.
So, Wing-yee
Tomlinson, Brian
Chan, Juliana C. N.
Ma, Ronald C. W.
The Hong Kong Diabetes Biobank Study Group
The Hong Kong Diabetes Register TRS Study Group
Hong Kong Diabetes Biobank Study Group
Hong Kong Diabetes Register TRS Study Group
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_0b2ae016f2954b74aecee230cb5cdc4f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0b2ae016f2954b74aecee230cb5cdc4f
Other Identifiers
ISSN
1756-994X
E-ISSN
1756-994X
DOI
10.1186/s13073-021-00831-z
