Kidney tumors associated with germline mutations of FH and SDHB show a CpG island methylator phenoty...
Kidney tumors associated with germline mutations of FH and SDHB show a CpG island methylator phenotype (CIMP)
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Germline mutations within the Krebs cycle enzyme genes fumarate hydratase (FH) or succinate dehydrogenase (SDHB, SDHC, SDHD) are associated with an increased risk of aggressive and early metastasizing variants of renal cell carcinoma (RCC). These RCCs express significantly increased levels of intracellular fumarate or succinate that inhibit 2-oxogl...
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Kidney tumors associated with germline mutations of FH and SDHB show a CpG island methylator phenotype (CIMP)
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TN_cdi_doaj_primary_oai_doaj_org_article_0be1cdbe7b5840ebaf72c63a9f4e65ac
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0be1cdbe7b5840ebaf72c63a9f4e65ac
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0278108
