Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase...
Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
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Author / Creator
Kim, Jong Hyun , Lee, Chulho , Lee, Minji , Wang, Haipeng , Kim, Kibum , Park, Seung Joon , Yoon, Ina , Jang, Jayun , Zhao, Hanchao , Kim, Hoi Kyoung , Kwon, Nam Hoon , Jeong, Seung Jae , Yoo, Hee Chan , Kim, Jae Hyun , Yang, Jee Sun , Lee, Myeong Youl , Lee, Chang Woo , Yun, Jieun , Oh, Soo Jin , Kang, Jong Soon , Martinis, Susan A. , Hwang, Kwang Yeon , Guo, Min , Han, Gyoonhee , Han, Jung Min and Kim, Sunghoon
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Leucyl-tRNA synthetase (LRS) is known to function as leucine sensor in the mammalian target of rapamycin complex 1 (mTORC1) pathway. However, the pathophysiological significance of its activity is not well understood. Here, we demonstrate that the leucine sensor function for mTORC1 activation of LRS can be decoupled from its catalytic activity. We...
Alternative Titles
Full title
Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
Authors, Artists and Contributors
Author / Creator
Lee, Chulho
Lee, Minji
Wang, Haipeng
Kim, Kibum
Park, Seung Joon
Yoon, Ina
Jang, Jayun
Zhao, Hanchao
Kim, Hoi Kyoung
Kwon, Nam Hoon
Jeong, Seung Jae
Yoo, Hee Chan
Kim, Jae Hyun
Yang, Jee Sun
Lee, Myeong Youl
Lee, Chang Woo
Yun, Jieun
Oh, Soo Jin
Kang, Jong Soon
Martinis, Susan A.
Hwang, Kwang Yeon
Guo, Min
Han, Gyoonhee
Han, Jung Min
Kim, Sunghoon
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_0d36499938674c89bf88e38b120784b7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0d36499938674c89bf88e38b120784b7
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00785-0
