An extended APOBEC3A mutation signature in cancer
An extended APOBEC3A mutation signature in cancer
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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APOBEC mutagenesis, a major driver of cancer evolution, is known for targeting TpC sites in DNA. Recently, we showed that APOBEC3A (A3A) targets DNA hairpin loops. Here, we show that DNA secondary structure is in fact an orthogonal influence on A3A substrate optimality and, surprisingly, can override the TpC sequence preference. VpC (non-TpC) sites...
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An extended APOBEC3A mutation signature in cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_0df7d51a696e4dfaa11c6266dbb37d50
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0df7d51a696e4dfaa11c6266dbb37d50
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-21891-0
