Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes
Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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NLRP1 and CARD8 are related cytosolic sensors that upon activation form supramolecular signalling complexes known as canonical inflammasomes, resulting in caspase−1 activation, cytokine maturation and/or pyroptotic cell death. NLRP1 and CARD8 use their C-terminal (CT) fragments containing a caspase recruitment domain (CARD) and the UPA (conserved i...
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Full title
Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes
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TN_cdi_doaj_primary_oai_doaj_org_article_0e61c5714aba4c07951365c347f3e523
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_0e61c5714aba4c07951365c347f3e523
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-20320-y
