Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interact...
Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Anti-IgE therapeutics interfere with the ability of IgE to bind to its receptors on effector cells. Here we report the crystal structure of an anti-IgE single-domain antibody in complex with an IgE Fc fragment, revealing how the antibody inhibits interactions between IgE and the two receptors FcεRI and CD23. The epitope overlaps only slightly with...
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Full title
Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction
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TN_cdi_doaj_primary_oai_doaj_org_article_100e1c2461b14a39be4cdf8caf230db8
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_100e1c2461b14a39be4cdf8caf230db8
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-02312-7
