Safety, tolerability and immunogenicity of an active anti-Aβ40 vaccine (ABvac40) in patients with Al...
Safety, tolerability and immunogenicity of an active anti-Aβ40 vaccine (ABvac40) in patients with Alzheimer’s disease: a randomised, double-blind, placebo-controlled, phase I trial
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Author / Creator
Lacosta, Ana-María , Pascual-Lucas, María , Pesini, Pedro , Casabona, Diego , Pérez-Grijalba, Virginia , Marcos-Campos, Iván , Sarasa, Leticia , Canudas, Jesus , Badi, Hassnae , Monleón, Inmaculada , San-José, Itziar , Munuera, Josep , Rodríguez-Gómez, Octavio , Abdelnour, Carla , Lafuente, Asunción , Buendía, Mar , Boada, Mercè , Tárraga, Lluis , Ruiz, Agustín and Sarasa, Manuel
Publisher
London: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
London: BioMed Central Ltd
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More information
Scope and Contents
Contents
BACKGROUNDImmunotherapy targeting the amyloid-β (Aβ) peptide is a promising strategy for the treatment of Alzheimer's disease (AD); however, none of the active or passive vaccines tested have been demonstrated to be effective to date. We have developed the first active vaccine against the C-terminal end of Aβ40, ABvac40, and assessed its safety and...
Alternative Titles
Full title
Safety, tolerability and immunogenicity of an active anti-Aβ40 vaccine (ABvac40) in patients with Alzheimer’s disease: a randomised, double-blind, placebo-controlled, phase I trial
Authors, Artists and Contributors
Author / Creator
Pascual-Lucas, María
Pesini, Pedro
Casabona, Diego
Pérez-Grijalba, Virginia
Marcos-Campos, Iván
Sarasa, Leticia
Canudas, Jesus
Badi, Hassnae
Monleón, Inmaculada
San-José, Itziar
Munuera, Josep
Rodríguez-Gómez, Octavio
Abdelnour, Carla
Lafuente, Asunción
Buendía, Mar
Boada, Mercè
Tárraga, Lluis
Ruiz, Agustín
Sarasa, Manuel
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_1030c599a5ae4b4d8f002a265d9af497
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1030c599a5ae4b4d8f002a265d9af497
Other Identifiers
ISSN
1758-9193
E-ISSN
1758-9193
DOI
10.1186/s13195-018-0340-8
