MYH10 activation rescues contractile defects in arrhythmogenic cardiomyopathy (ACM)
MYH10 activation rescues contractile defects in arrhythmogenic cardiomyopathy (ACM)
About this item
Full title
Author / Creator
García-Quintáns, Nieves , Sacristán, Silvia , Márquez-López, Cristina , Sánchez-Ramos, Cristina , Martinez-de-Benito, Fernando , Siniscalco, David , González-Guerra, Andrés , Camafeita, Emilio , Roche-Molina, Marta , Lytvyn, Mariya , Morera, David , Guillen, María I. , Sanguino, María A. , Sanz-Rosa, David , Martín-Pérez, Daniel , Garcia, Ricardo and Bernal, Juan A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The most prevalent genetic form of inherited arrhythmogenic cardiomyopathy (ACM) is caused by mutations in desmosomal
plakophilin-2
(
PKP2
). By studying pathogenic deletion mutations in the desmosomal protein PKP2, here we identify a general mechanism by which PKP2 delocalization restricts actomyosin network organization and cardiac sa...
Alternative Titles
Full title
MYH10 activation rescues contractile defects in arrhythmogenic cardiomyopathy (ACM)
Authors, Artists and Contributors
Author / Creator
Sacristán, Silvia
Márquez-López, Cristina
Sánchez-Ramos, Cristina
Martinez-de-Benito, Fernando
Siniscalco, David
González-Guerra, Andrés
Camafeita, Emilio
Roche-Molina, Marta
Lytvyn, Mariya
Morera, David
Guillen, María I.
Sanguino, María A.
Sanz-Rosa, David
Martín-Pérez, Daniel
Garcia, Ricardo
Bernal, Juan A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_10b925caee94464b82505e99e6d84978
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_10b925caee94464b82505e99e6d84978
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-41981-5
