Safety and anti-tumour activity of the IgE antibody MOv18 in patients with advanced solid tumours ex...
Safety and anti-tumour activity of the IgE antibody MOv18 in patients with advanced solid tumours expressing folate receptor-alpha: a phase I trial
About this item
Full title
Author / Creator
Spicer, James , Basu, Bristi , Montes, Ana , Banerji, Udai , Kristeleit, Rebecca , Miller, Rowan , Veal, Gareth J. , Corrigan, Christopher J. , Till, Stephen J. , Figini, Mariangela , Canevari, Silvana , Barton, Claire , Jones, Paul , Mellor, Sarah , Carroll, Simon , Selkirk, Chris , Nintos, George , Kwatra, Vineet , Funingana, Ionut-Gabriel , Doherty, Gary , Gould, Hannah J. , Pellizzari, Giulia , Nakamura, Mano , Ilieva, Kristina M. , Khiabany, Atousa , Stavraka, Chara , Chauhan, Jitesh , Gillett, Cheryl , Pinder, Sarah , Bax, Heather J. , Josephs, Debra H. and Karagiannis, Sophia N.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
All antibodies approved for cancer therapy are monoclonal IgGs but the biology of IgE, supported by comparative preclinical data, offers the potential for enhanced effector cell potency. Here we report a Phase I dose escalation trial (NCT02546921) with the primary objective of exploring the safety and tolerability of MOv18 IgE, a chimeric first-in-...
Alternative Titles
Full title
Safety and anti-tumour activity of the IgE antibody MOv18 in patients with advanced solid tumours expressing folate receptor-alpha: a phase I trial
Authors, Artists and Contributors
Author / Creator
Basu, Bristi
Montes, Ana
Banerji, Udai
Kristeleit, Rebecca
Miller, Rowan
Veal, Gareth J.
Corrigan, Christopher J.
Till, Stephen J.
Figini, Mariangela
Canevari, Silvana
Barton, Claire
Jones, Paul
Mellor, Sarah
Carroll, Simon
Selkirk, Chris
Nintos, George
Kwatra, Vineet
Funingana, Ionut-Gabriel
Doherty, Gary
Gould, Hannah J.
Pellizzari, Giulia
Nakamura, Mano
Ilieva, Kristina M.
Khiabany, Atousa
Stavraka, Chara
Chauhan, Jitesh
Gillett, Cheryl
Pinder, Sarah
Bax, Heather J.
Josephs, Debra H.
Karagiannis, Sophia N.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_10c6fe5134614037a52da348794ee12d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_10c6fe5134614037a52da348794ee12d
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-39679-9
