A circular RNA generated from an intron of the insulin gene controls insulin secretion
A circular RNA generated from an intron of the insulin gene controls insulin secretion
About this item
Full title
Author / Creator
Stoll, Lisa , Rodríguez-Trejo, Adriana , Guay, Claudiane , Brozzi, Flora , Bayazit, Mustafa Bilal , Gattesco, Sonia , Menoud, Véronique , Sobel, Jonathan , Marques, Ana Claudia , Venø, Morten Trillingsgaard , Esguerra, Jonathan Lou S. , Barghouth, Mohammad , Suleiman, Mara , Marselli, Lorella , Kjems, Jørgen , Eliasson, Lena , Renström, Erik , Bouzakri, Karim , Pinget, Michel , Marchetti, Piero , Regazzi, Romano , Faculty of Medicine , Medicinska fakulteten , Strategiska forskningsområden (SFO) , Diabetes - Islet Patophysiology , Institutionen för kliniska vetenskaper, Malmö , Strategic research areas (SRA) , Lunds universitet , Diabetes - öcellsexocytos , Profilområden och andra starka forskningsmiljöer , Lund University , EXODIAB: Excellence of Diabetes Research in Sweden , Diabetes - öpatofysiologi , NanoLund: Centre for Nanoscience , Diabetes - Islet Cell Exocytosis , Profile areas and other strong research environments and Department of Clinical Sciences, Malmö
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Fine-tuning of insulin release from pancreatic β-cells is essential to maintain blood glucose homeostasis. Here, we report that insulin secretion is regulated by a circular RNA containing the lariat sequence of the second intron of the insulin gene. Silencing of this intronic circular RNA in pancreatic islets leads to a decrease in the expression o...
Alternative Titles
Full title
A circular RNA generated from an intron of the insulin gene controls insulin secretion
Authors, Artists and Contributors
Author / Creator
Rodríguez-Trejo, Adriana
Guay, Claudiane
Brozzi, Flora
Bayazit, Mustafa Bilal
Gattesco, Sonia
Menoud, Véronique
Sobel, Jonathan
Marques, Ana Claudia
Venø, Morten Trillingsgaard
Esguerra, Jonathan Lou S.
Barghouth, Mohammad
Suleiman, Mara
Marselli, Lorella
Kjems, Jørgen
Eliasson, Lena
Renström, Erik
Bouzakri, Karim
Pinget, Michel
Marchetti, Piero
Regazzi, Romano
Faculty of Medicine
Medicinska fakulteten
Strategiska forskningsområden (SFO)
Diabetes - Islet Patophysiology
Institutionen för kliniska vetenskaper, Malmö
Strategic research areas (SRA)
Lunds universitet
Diabetes - öcellsexocytos
Profilområden och andra starka forskningsmiljöer
Lund University
EXODIAB: Excellence of Diabetes Research in Sweden
Diabetes - öpatofysiologi
NanoLund: Centre for Nanoscience
Diabetes - Islet Cell Exocytosis
Profile areas and other strong research environments
Department of Clinical Sciences, Malmö
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_114bb60757e446fba74489bec09b7aca
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_114bb60757e446fba74489bec09b7aca
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-19381-w
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