Quantification of protein abundance and interaction defines a mechanism for operation of the circadi...
Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock
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Publisher
England: eLife Sciences Publications, Ltd
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Language
English
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England: eLife Sciences Publications, Ltd
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The mammalian circadian clock exerts control of daily gene expression through cycles of DNA binding. Here, we develop a quantitative model of how a finite pool of BMAL1 protein can regulate thousands of target sites over daily time scales. We used quantitative imaging to track dynamic changes in endogenous labelled proteins across peripheral tissue...
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Full title
Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock
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TN_cdi_doaj_primary_oai_doaj_org_article_12909e7319834f59a2d8e05b4469036f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_12909e7319834f59a2d8e05b4469036f
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.73976
