Tissue-based genomic profiling of 300,000 tumors highlights the detection of variants with low allel...
Tissue-based genomic profiling of 300,000 tumors highlights the detection of variants with low allele fraction
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Tumor tissues obtained in the clinical setting typically have low purity and display treatment-associated genetic heterogeneity, contributing to variants at low variant allele fractions (VAF). We present a pan-cancer landscape and the therapeutic impact of somatic variants detected at low VAF (≤10%) from tumor tissues in 331,503 patients, across 78...
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Tissue-based genomic profiling of 300,000 tumors highlights the detection of variants with low allele fraction
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TN_cdi_doaj_primary_oai_doaj_org_article_13c3694e1d8f4eb3a9edc367aad1dadb
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_13c3694e1d8f4eb3a9edc367aad1dadb
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ISSN
2397-768X
E-ISSN
2397-768X
DOI
10.1038/s41698-025-00991-w
