Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics
Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Macrolides and ketolides comprise a family of clinically important antibiotics that inhibit protein synthesis by binding within the exit tunnel of the bacterial ribosome. While these antibiotics are known to interrupt translation at specific sequence motifs, with ketolides predominantly stalling at Arg/Lys-X-Arg/Lys motifs and macrolides displaying...
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Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics
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TN_cdi_doaj_primary_oai_doaj_org_article_15117e74a84f4129bf14254d7d049216
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_15117e74a84f4129bf14254d7d049216
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-24674-9
