Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against gliobla...
Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma
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Author / Creator
Beug, Shawn T. , Beauregard, Caroline E. , Healy, Cristin , Sanda, Tarun , St-Jean, Martine , Chabot, Janelle , Walker, Danielle E. , Mohan, Aditya , Earl, Nathalie , Lun, Xueqing , Senger, Donna L. , Robbins, Stephen M. , Staeheli, Peter , Forsyth, Peter A. , Alain, Tommy , LaCasse, Eric C. and Korneluk, Robert G.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Small-molecule inhibitor of apoptosis (IAP) antagonists, called Smac mimetic compounds (SMCs), sensitize tumours to TNF-α-induced killing while simultaneously blocking TNF-α growth-promoting activities. SMCs also regulate several immunomodulatory properties within immune cells. We report that SMCs synergize with innate immune stimulants and immune...
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Full title
Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma
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TN_cdi_doaj_primary_oai_doaj_org_article_153f1f0b72134cffba06e3aad0670491
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_153f1f0b72134cffba06e3aad0670491
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms14278
