XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis
XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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A distinct 12-hour clock exists in addition to the 24-hour circadian clock to coordinate metabolic and stress rhythms. Here, we show that liver-specific ablation of X-box binding protein 1 (XBP1) disrupts the hepatic 12-hour clock and promotes spontaneous non-alcoholic fatty liver disease (NAFLD). We show that hepatic XBP1 predominantly regulates t...
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XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis
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TN_cdi_doaj_primary_oai_doaj_org_article_163c3b3fcdb943638dd992aefa6a597d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_163c3b3fcdb943638dd992aefa6a597d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-20028-z
