Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and c...
Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance
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Author / Creator
Li, Shun , Song, Ying , Quach, Christine , Guo, Hongrui , Jang, Gyu-Beom , Maazi, Hadi , Zhao, Shihui , Sands, Nathaniel A. , Liu, Qingsong , In, Gino K. , Peng, David , Yuan, Weiming , Machida, Keigo , Yu, Min , Akbari, Omid , Hagiya, Ashley , Yang, Yongfei , Punj, Vasu , Tang, Liling and Liang, Chengyu
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Autophagy maintains homeostasis and is induced upon stress. Yet, its mechanistic interaction with oncogenic signaling remains elusive. Here, we show that in BRAF
V600E
-melanoma, autophagy is induced by BRAF inhibitor (BRAFi), as part of a transcriptional program coordinating lysosome biogenesis/function, mediated by the TFEB transcription fa...
Alternative Titles
Full title
Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_16402280b75e478390036fae4511579a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_16402280b75e478390036fae4511579a
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09634-8
