Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent chann...
Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity
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Author / Creator
Goretzki, Benedikt , Wiedemann, Christoph , McCray, Brett A. , Schäfer, Stefan L. , Jansen, Jasmin , Tebbe, Frederike , Mitrovic, Sarah-Ana , Nöth, Julia , Cabezudo, Ainara Claveras , Donohue, Jack K. , Jeffries, Cy M. , Steinchen, Wieland , Stengel, Florian , Sumner, Charlotte J. , Hummer, Gerhard and Hellmich, Ute A.
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Intrinsically disordered regions (IDRs) are essential for membrane receptor regulation but often remain unresolved in structural studies. TRPV4, a member of the TRP vanilloid channel family involved in thermo- and osmosensation, has a large N-terminal IDR of approximately 150 amino acids. With an integrated structural biology approach, we analyze t...
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Full title
Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity
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TN_cdi_doaj_primary_oai_doaj_org_article_164d0c141a984b619e153ae313a859dd
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_164d0c141a984b619e153ae313a859dd
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-39808-4
