Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical m...
Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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APOE and Trem2 are major genetic risk factors for Alzheimer’s disease (AD), but how they affect microglia response to Aβ remains unclear. Here we report an APOE isoform-specific phospholipid signature with correlation between human
APOEε3/3
and
APOEε4/4
AD brain and lipoproteins from astrocyte conditioned media of APOE3 and APOE4 mice....
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Full title
Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease
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TN_cdi_doaj_primary_oai_doaj_org_article_16908adbabbe48e7b4e51149f560d6dc
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_16908adbabbe48e7b4e51149f560d6dc
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-23762-0
