CK1δ/ε-mediated TDP-43 phosphorylation contributes to early motor neuron disease toxicity in amyotro...
CK1δ/ε-mediated TDP-43 phosphorylation contributes to early motor neuron disease toxicity in amyotrophic lateral sclerosis
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Publisher
England: BioMed Central
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Language
English
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England: BioMed Central
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Contents
Hyperphosphorylated TDP-43 aggregates in the cytoplasm of motor neurons is a neuropathological signature of amyotrophic lateral sclerosis (ALS). These aggregates have been proposed to possess a toxic disease driving role in ALS pathogenesis and progression, however, the contribution of phosphorylation to TDP-43 aggregation and ALS disease mechanism...
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Full title
CK1δ/ε-mediated TDP-43 phosphorylation contributes to early motor neuron disease toxicity in amyotrophic lateral sclerosis
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TN_cdi_doaj_primary_oai_doaj_org_article_17177069406246b98dc553421a5e2fb8
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_17177069406246b98dc553421a5e2fb8
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ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-024-01902-z
