Synthesis and Biological Evaluation of Fangchinoline Derivatives as Anti-Inflammatory Agents through...
Synthesis and Biological Evaluation of Fangchinoline Derivatives as Anti-Inflammatory Agents through Inactivation of Inflammasome
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
Twenty eight 7-substitued fangchinoline analogues, of which twenty two were novel, were synthesized and evaluated for their effect to inhibit lipopolysaccharide/nigericin (LPS/NIG)-induced IL-1β release at both cell and protein levels at the concentration of 5 μM. Among them, compound
exhibited promising inhibitory potency against IL-β activatio...
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Full title
Synthesis and Biological Evaluation of Fangchinoline Derivatives as Anti-Inflammatory Agents through Inactivation of Inflammasome
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TN_cdi_doaj_primary_oai_doaj_org_article_178a0955bea54001b9d1c978938021b5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_178a0955bea54001b9d1c978938021b5
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ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules24061154
