Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of...
Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Metastatic colonization relies on interactions between disseminated cancer cells and the microenvironment in secondary organs. Here, we show that disseminated breast cancer cells evoke phenotypic changes in lung fibroblasts, forming a supportive metastatic niche. Colonization of the lungs confers an inflammatory phenotype in metastasis-associated f...
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Full title
Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs
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TN_cdi_doaj_primary_oai_doaj_org_article_17acb7c31f7941f0959b5034c6bfd4bc
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_17acb7c31f7941f0959b5034c6bfd4bc
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-15188-x
