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Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of...

Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_17acb7c31f7941f0959b5034c6bfd4bc

Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs

About this item

Full title

Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2020-03, Vol.11 (1), p.1494-1494, Article 1494

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Metastatic colonization relies on interactions between disseminated cancer cells and the microenvironment in secondary organs. Here, we show that disseminated breast cancer cells evoke phenotypic changes in lung fibroblasts, forming a supportive metastatic niche. Colonization of the lungs confers an inflammatory phenotype in metastasis-associated f...

Alternative Titles

Full title

Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_17acb7c31f7941f0959b5034c6bfd4bc

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_17acb7c31f7941f0959b5034c6bfd4bc

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-020-15188-x

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