Treatment- and population-specific genetic risk factors for anti-drug antibodies against interferon-...
Treatment- and population-specific genetic risk factors for anti-drug antibodies against interferon-beta: a GWAS
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Author / Creator
ABIRISK consortium , on behalf of the ABIRISK consortium , Andlauer, Till F M , Link, Jenny , Martin, Dorothea , Ryner, Malin , Hermanrud, Christina , Grummel, Verena , Auer, Michael , Hegen, Harald , Aly, Lilian , Gasperi, Christiane , Knier, Benjamin , Müller-Myhsok, Bertram , Jensen, Poul Erik Hyldgaard , Sellebjerg, Finn , Kockum, Ingrid , Olsson, Tomas , Pallardy, Marc , Spindeldreher, Sebastian , Deisenhammer, Florian , Fogdell-Hahn, Anna and Hemmer, Bernhard
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central Ltd
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More information
Scope and Contents
Contents
Upon treatment with biopharmaceuticals, the immune system may produce anti-drug antibodies (ADA) that inhibit the therapy. Up to 40% of multiple sclerosis patients treated with interferon β (IFNβ) develop ADA, for which a genetic predisposition exists. Here, we present a genome-wide association study on ADA and predict the occurrence of antibodies...
Alternative Titles
Full title
Treatment- and population-specific genetic risk factors for anti-drug antibodies against interferon-beta: a GWAS
Authors, Artists and Contributors
Author / Creator
on behalf of the ABIRISK consortium
Andlauer, Till F M
Link, Jenny
Martin, Dorothea
Ryner, Malin
Hermanrud, Christina
Grummel, Verena
Auer, Michael
Hegen, Harald
Aly, Lilian
Gasperi, Christiane
Knier, Benjamin
Müller-Myhsok, Bertram
Jensen, Poul Erik Hyldgaard
Sellebjerg, Finn
Kockum, Ingrid
Olsson, Tomas
Pallardy, Marc
Spindeldreher, Sebastian
Deisenhammer, Florian
Fogdell-Hahn, Anna
Hemmer, Bernhard
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_17f0b4a115a9411898d869c49bd392a4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_17f0b4a115a9411898d869c49bd392a4
Other Identifiers
ISSN
1741-7015
E-ISSN
1741-7015
DOI
10.1186/s12916-020-01769-6
