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HOPS-Dependent Endosomal Escape Demands Protein Unfolding

HOPS-Dependent Endosomal Escape Demands Protein Unfolding

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_18471f915d2747cabc245b87e7164be4

HOPS-Dependent Endosomal Escape Demands Protein Unfolding

About this item

Full title

HOPS-Dependent Endosomal Escape Demands Protein Unfolding

Publisher

United States: American Chemical Society

Journal title

ACS central science, 2024-04, Vol.10 (4), p.860-870

Language

English

Formats

Publication information

Publisher

United States: American Chemical Society

More information

Scope and Contents

Contents

The inefficient translocation of proteins across biological membranes limits their application as potential therapeutics and research tools. In many cases, the translocation of a protein involves two discrete steps: uptake into the endocytic pathway and endosomal escape. Certain charged or amphiphilic molecules can achieve high protein uptake, but...

Alternative Titles

Full title

HOPS-Dependent Endosomal Escape Demands Protein Unfolding

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_18471f915d2747cabc245b87e7164be4

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_18471f915d2747cabc245b87e7164be4

Other Identifiers

ISSN

2374-7943

E-ISSN

2374-7951

DOI

10.1021/acscentsci.4c00016

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