The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites
The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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G-protein-coupled receptors do not only feature the orthosteric pockets, where most endogenous agonists bind, but also a multitude of other allosteric pockets that have come into the focus as potential binding sites for synthetic modulators. Here, to better characterise such pockets, we investigate 557 GPCR structures by exhaustively docking small...
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The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites
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TN_cdi_doaj_primary_oai_doaj_org_article_18859e7428cc429ab666084d30afc674
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_18859e7428cc429ab666084d30afc674
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-29609-6
