Neoantigen architectures define immunogenicity and drive immune evasion of tumors with heterogenous...
Neoantigen architectures define immunogenicity and drive immune evasion of tumors with heterogenous neoantigen expression
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Publisher
England: BMJ Publishing Group Ltd
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Language
English
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Publisher
England: BMJ Publishing Group Ltd
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BackgroundIntratumoral heterogeneity (ITH) and subclonal antigen expression blunt antitumor immunity and are associated with poor responses to immune-checkpoint blockade immunotherapy (ICB) in patients with cancer. The underlying mechanisms however thus far remained elusive, preventing the design of novel treatment approaches for patients with high...
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Full title
Neoantigen architectures define immunogenicity and drive immune evasion of tumors with heterogenous neoantigen expression
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TN_cdi_doaj_primary_oai_doaj_org_article_188966450aff41ee8558bb8597cff9ab
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_188966450aff41ee8558bb8597cff9ab
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ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2024-010249
