Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5
Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The GTPase Rab11 plays key roles in receptor recycling, oogenesis, autophagosome formation, and ciliogenesis. However, investigating Rab11 regulation has been hindered by limited molecular detail describing activation by cognate guanine nucleotide exchange factors (GEFs). Here, we present the structure of Rab11 bound to the GEF SH3BP5, along with d...
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Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5
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TN_cdi_doaj_primary_oai_doaj_org_article_195d660c5d9c4b958c577bebd6f5b073
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_195d660c5d9c4b958c577bebd6f5b073
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-06196-z
