L1 retrotransposons exploit RNA m6A modification as an evolutionary driving force
L1 retrotransposons exploit RNA m6A modification as an evolutionary driving force
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Author / Creator
Hwang, Sung-Yeon , Jung, Hyunchul , Mun, Seyoung , Lee, Sungwon , Park, Kiwon , Baek, S. Chan , Moon, Hyungseok C. , Kim, Hyewon , Kim, Baekgyu , Choi, Yongkuk , Go, Young-Hyun , Tang, Wanxiangfu , Choi, Jongsu , Choi, Jung Kyoon , Cha, Hyuk-Jin , Park, Hye Yoon , Liang, Ping , Kim, V. Narry , Han, Kyudong and Ahn, Kwangseog
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
L1 retrotransposons can pose a threat to genome integrity. The host has evolved to restrict L1 replication. However, mechanisms underlying L1 propagation out of the host surveillance remains unclear. Here, we propose an evolutionary survival strategy of L1, which exploits RNA m
6
A modification. We discover that m
6
A ‘writer’ METTL3 fa...
Alternative Titles
Full title
L1 retrotransposons exploit RNA m6A modification as an evolutionary driving force
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TN_cdi_doaj_primary_oai_doaj_org_article_1961d00465714c29a8b1bed8e65a3309
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1961d00465714c29a8b1bed8e65a3309
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-21197-1
