Copper ions, prion protein and Aβ modulate Ca levels in central nervous system myelin in an NMDA rec...
Copper ions, prion protein and Aβ modulate Ca levels in central nervous system myelin in an NMDA receptor-dependent manner
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London: BioMed Central
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English
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London: BioMed Central
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As in neurons, CNS myelin expresses N-Methyl-D-Aspartate Receptors (NMDARs) that subserve physiological roles, but have the potential to induce injury to this vital element. Using 2-photon imaging of myelinic Ca in live ex vivo mouse optic nerves, we show that Cu ions potently modulate Ca levels in an NMDAR-dependent manner. Chelating Cu in the per...
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Full title
Copper ions, prion protein and Aβ modulate Ca levels in central nervous system myelin in an NMDA receptor-dependent manner
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TN_cdi_doaj_primary_oai_doaj_org_article_199b289fb7ee4988ba838224fe7e41a4
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_199b289fb7ee4988ba838224fe7e41a4
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ISSN
1756-6606
E-ISSN
1756-6606
DOI
10.1186/s13041-022-00955-2
