A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic...
A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine
About this item
Full title
Author / Creator
Sebastian, Carlos , Ferrer, Christina , Serra, Maria , Choi, Jee-Eun , Ducano, Nadia , Mira, Alessia , Shah, Manasvi S. , Stopka, Sylwia A. , Perciaccante, Andrew J. , Isella, Claudio , Moya-Rull, Daniel , Vara-Messler, Marianela , Giordano, Silvia , Maldi, Elena , Desai, Niyati , Capen, Diane E. , Medico, Enzo , Cetinbas, Murat , Sadreyev, Ruslan I. , Brown, Dennis , Rivera, Miguel N. , Sapino, Anna , Breault, David T. , Agar, Nathalie Y. R. and Mostoslavsky, Raul
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Although reprogramming of cellular metabolism is a hallmark of cancer, little is known about how metabolic reprogramming contributes to early stages of transformation. Here, we show that the histone deacetylase SIRT6 regulates tumor initiation during intestinal cancer by controlling glucose metabolism. Loss of SIRT6 results in an increase in the nu...
Alternative Titles
Full title
A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine
Authors, Artists and Contributors
Author / Creator
Ferrer, Christina
Serra, Maria
Choi, Jee-Eun
Ducano, Nadia
Mira, Alessia
Shah, Manasvi S.
Stopka, Sylwia A.
Perciaccante, Andrew J.
Isella, Claudio
Moya-Rull, Daniel
Vara-Messler, Marianela
Giordano, Silvia
Maldi, Elena
Desai, Niyati
Capen, Diane E.
Medico, Enzo
Cetinbas, Murat
Sadreyev, Ruslan I.
Brown, Dennis
Rivera, Miguel N.
Sapino, Anna
Breault, David T.
Agar, Nathalie Y. R.
Mostoslavsky, Raul
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_1ae650e5a5c942e78cc7775f36dd9685
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1ae650e5a5c942e78cc7775f36dd9685
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-29085-y
