Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis
Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) is an inhibitory immune-checkpoint molecule that suppresses CD4
+
and CD8
+
T cell activation when expressed on antigen-presenting cells.
Vsir
−/−
mice developed loss of peripheral tolerance and multi-organ chronic inflammatory phenotypes.
Vsir
−/−
CD4
...
Alternative Titles
Full title
Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis
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TN_cdi_doaj_primary_oai_doaj_org_article_1b0571cb47a145ed901429ee57439f62
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1b0571cb47a145ed901429ee57439f62
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-01411-1
