Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19
Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19
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Author / Creator
Mothes, Ronja , Pascual-Reguant, Anna , Koehler, Ralf , Liebeskind, Juliane , Liebheit, Alina , Bauherr, Sandy , Philipsen, Lars , Dittmayer, Carsten , Laue, Michael , von Manitius, Regina , Elezkurtaj, Sefer , Durek, Pawel , Heinrich, Frederik , Heinz, Gitta A. , Guerra, Gabriela M. , Obermayer, Benedikt , Meinhardt, Jenny , Ihlow, Jana , Radke, Josefine , Heppner, Frank L. , Enghard, Philipp , Stockmann, Helena , Aschman, Tom , Schneider, Julia , Corman, Victor M. , Sander, Leif E. , Mashreghi, Mir-Farzin , Conrad, Thomas , Hocke, Andreas C. , Niesner, Raluca A. , Radbruch, Helena and Hauser, Anja E.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Prolonged lung pathology has been associated with COVID-19, yet the cellular and molecular mechanisms behind this chronic inflammatory disease are poorly understood. In this study, we combine advanced imaging and spatial transcriptomics to shed light on the local immune response in severe COVID-19. We show that activated adventitial niches are cruc...
Alternative Titles
Full title
Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19
Authors, Artists and Contributors
Author / Creator
Pascual-Reguant, Anna
Koehler, Ralf
Liebeskind, Juliane
Liebheit, Alina
Bauherr, Sandy
Philipsen, Lars
Dittmayer, Carsten
Laue, Michael
von Manitius, Regina
Elezkurtaj, Sefer
Durek, Pawel
Heinrich, Frederik
Heinz, Gitta A.
Guerra, Gabriela M.
Obermayer, Benedikt
Meinhardt, Jenny
Ihlow, Jana
Radke, Josefine
Heppner, Frank L.
Enghard, Philipp
Stockmann, Helena
Aschman, Tom
Schneider, Julia
Corman, Victor M.
Sander, Leif E.
Mashreghi, Mir-Farzin
Conrad, Thomas
Hocke, Andreas C.
Niesner, Raluca A.
Radbruch, Helena
Hauser, Anja E.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_1b2247b6d5234d329b89d09ddd2a8d84
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1b2247b6d5234d329b89d09ddd2a8d84
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-36333-2
