Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safegua...
Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Despite their rapidly-expanding therapeutic potential, human pluripotent stem cell (hPSC)-derived cell therapies continue to have serious safety risks. Transplantation of hPSC-derived cell populations into preclinical models has generated teratomas (tumors arising from undifferentiated hPSCs), unwanted tissues, and other types of adverse events. Mi...
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Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards
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TN_cdi_doaj_primary_oai_doaj_org_article_1bf355be0de745bc987455ce3536745a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1bf355be0de745bc987455ce3536745a
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-16455-7
