NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1
NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Despite the substantial impact of post-translational modifications on programmed cell death 1 ligand 1 (PD-L1), its importance in therapeutic resistance in pancreatic cancer remains poorly defined. Here, we demonstrate that never in mitosis gene A-related kinase 2 (NEK2) phosphorylates PD-L1 to maintain its stability, causing PD-L1-targeted pancrea...
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NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1
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TN_cdi_doaj_primary_oai_doaj_org_article_1cd631eb781b4095bfc716c8f7c76317
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1cd631eb781b4095bfc716c8f7c76317
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-24769-3
