Identification of Potential Selective PAK4 Inhibitors Through Shape and Protein Conformation Ensembl...
Identification of Potential Selective PAK4 Inhibitors Through Shape and Protein Conformation Ensemble Screening and Electrostatic-Surface-Matching Optimization
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Switzerland: MDPI
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Language
English
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Publisher
Switzerland: MDPI
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Contents
P21-activated kinase 4 (PAK4) plays a crucial role in the proliferation and metastasis of various cancers. However, developing selective PAK4 inhibitors remains challenging due to the high homology within the PAK family. Therefore, developing highly selective PAK4 inhibitors is critical to overcoming the limitations of existing inhibitors. We analy...
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Full title
Identification of Potential Selective PAK4 Inhibitors Through Shape and Protein Conformation Ensemble Screening and Electrostatic-Surface-Matching Optimization
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TN_cdi_doaj_primary_oai_doaj_org_article_1f44f58d02224f96afcabae22399778d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1f44f58d02224f96afcabae22399778d
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ISSN
1467-3045,1467-3037
E-ISSN
1467-3045
DOI
10.3390/cimb47010029
