Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans...
Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Injury of CNS nerve tracts remodels circuitry through dendritic spine loss and hyper-excitability, thus influencing recovery. Due to the complexity of the CNS, a mechanistic understanding of injury-induced synaptic remodeling remains unclear. Using microfluidic chambers to separate and injure distal axons, we show that axotomy causes retrograde den...
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Full title
Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling
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TN_cdi_doaj_primary_oai_doaj_org_article_1f87dabee91b461a89a2e1999bf53396
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1f87dabee91b461a89a2e1999bf53396
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00652-y
